Open AccessNo Bones About It: Insulin Modulates Skeletal Remodeling
Author(s) -
Clifford J. Rosen,
Katherine J. Motyl
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.07.001
Subject(s) - osteocalcin , bone remodeling , bone resorption , homeostasis , endocrinology , biology , medicine , insulin , mediator , alkaline phosphatase , biochemistry , enzyme
Advancing the hypothesis that bone remodeling is intimately linked to metabolic homeostasis, Fulzele et al. (2010) and Ferron et al. (2010) present evidence that insulin signaling promotes the activation of bone-forming osteoblasts and enhances production of osteocalcin, a secreted mediator of insulin sensitivity, through modulation of bone resorption.
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