SnapShot: Formins

See online version for legend and references. Autosomal-dominant nonsyndromic deafness (DFNA1), myeloproliferative defects, defects in T lymphocyte traffi cking and proliferation, tumor cell invasion, defects in natural killer lymphocyte function DIAPH2 (mDia3) Cdc42 Kinetochore Stable microtubule attachment to kinetochore for chromosome alignment Premature ovarian failure DIAPH3 (mDia2) Increased chromosomal deletion of gene locus in metastatic tumors FMNL1 (FRLα) Cdc42 Cell cortex, microtubule-organizing center Phagocytosis, T cell polarity Overexpression is linked to leukemia and non-Hodgkin lymphoma FMNL2/FRL3/ FHOD2 RhoC ND Cell motility Upregulated in metastatic colorectal cancer, chromosomal deletion is associated with mental retardation FMNL3/FRL2 Constituently active Stress fi bers ND ND DAAM1 Dishevelled Cell cortex Planar cell polarity ND DAAM2 ND ND ND Overexpressed in schizophrenia patients FHOD1 ROCK Stress fi bers Cell motility FHOD3 ND Nestin, sarcomere Organizing sarcomeres in striated muscle cells Single-nucleotide polymorphisms associated with type 1 diabetes FMN1 Spire* Adherens junctions, microtubules Forming intercellular junctions Oligodactylism and partial renal agenesis FMN2 Spire* Chromosomes Asymmetric spindle positioning in meiotic oocytes, cytokinesis Female infertility, birth defects Delphilin ND Postsynapse Synaptic transmission Defects in Induction of long-term depression and optokinetic adaptation INF1/FHDC1 ND Microtubules Microtubule stabilization ND INF2 Cdc42 ER, apical zone, slit diaphragm ER structure, cell polarity, transcytosis, and lumen formation Mutated in patients with focal segmental glomerulosclerosis