Open AccessMetabolic Networks of Longevity
Author(s) -
Riekelt H. Houtkooper,
Robert W. Williams,
Johan Auwerx
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.06.029
Subject(s) - longevity , biology , life expectancy , disease , life span , bioinformatics , evolutionary biology , genetics , environmental health , medicine , population
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.
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