Open AccessD'oh! Genes and Environment Cause Crohn's Disease
Author(s) -
John A. Todd
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.06.015
Subject(s) - biology , disease , gene , genome wide association study , genome , genetics , genotyping , immunology , single nucleotide polymorphism , genotype , medicine , pathology
Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases by identifying genes that predispose individuals to these disorders. Cadwell et al. (2010) now demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility gene collude to cause inflammatory disease in the mouse gut.
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