Open AccessAlzheimer's Disease Neurons Fail the Acid Test
Author(s) -
Wim Annaert,
Bart De Strooper
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.06.009
Subject(s) - biology , presenilin , disease , amyloid (mycology) , alzheimer's disease , amyloid precursor protein , gene , neuroscience , mutation , genetics , microbiology and biotechnology , medicine , botany
Mutations in the presenilin genes are the most common cause of familial forms of Alzheimer's disease. Although it is well known for its role in the generation of amyloid peptide, Lee et al. (2010) now report that presenilin 1 deficiency also impacts maturation of the lysosomal proton pump, affecting autophagocytosis and protein turnover.
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