Open AccessA Twist on Potassium Channel Gating
Author(s) -
Wei Zhou,
Lily Yeh Jan
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.05.038
Subject(s) - biology , gating , potassium channel , twist , channel (broadcasting) , potassium , biophysics , genetics , geometry , telecommunications , chemistry , mathematics , organic chemistry , computer science
The selectivity filter of potassium channels, the narrowest segment of the pore, permits only potassium ions to diffuse through the pore. Clarke et al. (2010) now present 11 structures of an inwardly rectifying potassium channel, providing evidence that the selectivity filter functions in channel gating and conformational changes in the cytoplasmic domains correlate with pore opening.
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