SnapShot: Neuroligin-Neurexin Complexes | Zendy

Stéphane J. Baudouin | Zendy; Peter Scheiffele | Zendy

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SnapShot: Neuroligin-Neurexin Complexes

Author(s) -

Stéphane J. Baudouin,

Peter Scheiffele

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.05.024

Subject(s) - biology , neuroligin , neurexin , snapshot (computer storage) , evolutionary biology , neuroscience , genetics , computer science , excitatory postsynaptic potential , receptor , postsynaptic potential , inhibitory postsynaptic potential , operating system

The neuroligin-neurexin complex is a heterophilic adhesion system at neuronal synapses. Both neuroligins and neurexins have synaptogenic activities that organize pre- and postsynaptic compartments in a bidirectional manner. Multiple genes, alternative promoters, and extensive alternative splicing generate neuroligin and neurexin variants that may underlie synapse-specific functions. In human patients, mutations in neuroligin and neurexin genes are associated with neurodevelopmental disorders, highlighting the importance of these proteins for cognitive function.

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