Quantitative Genetic Interactions Reveal Biological Modularity | Zendy

Pedro Beltrão | Zendy; Gerard Cagney | Zendy; Nevan J. Krogan | Zendy

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Quantitative Genetic Interactions Reveal Biological Modularity

Author(s) -

Pedro Beltrão,

Gerard Cagney,

Nevan J. Krogan

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.05.019

Subject(s) - reductionism , scope (computer science) , modularity (biology) , biology , universe , biological data , data science , computer science , evolutionary biology , astrophysics , epistemology , physics , bioinformatics , philosophy , programming language

Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

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