Viral Defense: It Takes Two MAVS to Tango | Zendy

Shruti Sharma | Zendy; Katherine A. Fitzgerald | Zendy

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Viral Defense: It Takes Two MAVS to Tango

Author(s) -

Shruti Sharma,

Katherine A. Fitzgerald

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.04.043

Subject(s) - biology , viral replication , microbiology and biotechnology , signal transducing adaptor protein , peroxisome , mitochondrion , antiviral protein , virology , signal transduction , virus , gene , genetics , rna

To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.

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