Open AccessAnchoring Local Translation in Neurons
Author(s) -
Kelsey C. Martin
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.04.031
Subject(s) - netrin , biology , translation (biology) , extracellular , growth cone , microbiology and biotechnology , neuroscience , biological neural network , axon guidance , gene , axon , messenger rna , genetics
In probing how protein synthesis in neurons is coupled to extracellular stimuli, Tcherkezian et al. (2010) discover that the receptor protein DCC anchors components of the translation machinery at the plasma membrane. Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis.
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