Open AccessRegulation of RNA Polymerase II Elongation by c-Myc
Author(s) -
David H. Price
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.04.016
Subject(s) - biology , rna polymerase ii , elongation , polymerase , rna polymerase , rna , rna polymerase i , microbiology and biotechnology , genetics , gene expression , gene , promoter , materials science , ultimate tensile strength , metallurgy
The genome-wide mapping presented in this issue by Rahl et al. (2010) demonstrates how the transcription factor c-Myc interfaces with the machinery that controls RNA polymerase II elongation. These findings account for the ability of c-Myc to activate the expression of a large number of genes that promote rapid proliferation.
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