Open AccessEpigenetics Drives RAGs to Recombination Riches
Author(s) -
Mark S. Schlissel
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.04.014
Subject(s) - rag2 , recombination activating gene , v(d)j recombination , biology , chromatin , recombination signal sequences , microbiology and biotechnology , recombination , histone , gene rearrangement , gene , dna , genetics
V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages of lymphoid development.
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