Open AccessGuiding Endosomal Maturation
Author(s) -
Margarita Cabrera,
Christian Ungermann
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.04.013
Subject(s) - endosome , rab , endocytic cycle , microbiology and biotechnology , biology , endocytosis , gtpase , golgi apparatus , small gtpase , signal transduction , cell , biochemistry , intracellular , endoplasmic reticulum
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
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