Anti-inflammatory Agents: Present and Future | Zendy

Charles A. Dinarello | Zendy

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Anti-inflammatory Agents: Present and Future

Author(s) -

Charles A. Dinarello

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.02.043

Subject(s) - inflammation , biology , histone deacetylase , anti inflammatory , aspirin , drug development , drug discovery , nonsteroidal , immunology , disease , immune system , pharmacology , drug , bioinformatics , histone , medicine , biochemistry , gene

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.

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