SnapShot: Nucleotide Excision Repair | Zendy

Caixia Guo | Zendy; Tie-Shan Tang | Zendy; Errol C. Friedberg | Zendy

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SnapShot: Nucleotide Excision Repair

Author(s) -

Caixia Guo,

Tie-Shan Tang,

Errol C. Friedberg

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.02.033

Subject(s) - biology , snapshot (computer storage) , nucleotide excision repair , genetics , computational biology , dna repair , gene , database , computer science

Nucleotide excision repair (NER) was discovered in both prokaryotes and eukaryotes in the 1960s (Friedberg et al., 2005). The process corrects a wide spectrum of damage to DNA bases that results in distortions in the native conformation of DNA, including damage induced by ultraviolet (UV) light and by a plethora of chemicals. NER comprises two distinct subpathways. Global genome repair (GGR) repairs lesions in regions of the genome that are transcriptionally silent, and transcription-coupled repair (TCR) repairs lesions in regions of the genome that are transcriptionally active. A key difference between these two NER pathways is the molecular mechanism used to recognize the damaged base (designated by a red star in the SnapShot figure).

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