Open AccessTB: Screening for Responses to a Vile Visitor
Author(s) -
Marcel A. Behr,
Erwin Schurr,
Philippe Gros
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.02.030
Subject(s) - tuberculosis , mycobacterium tuberculosis , biology , virulence , leprosy , immune system , microbiology and biotechnology , immunology , genetics , medicine , gene , pathology
Mycobacteria, the pathogens that cause tuberculosis and leprosy, establish long-term infections in host macrophages. Recent studies, including two genetic screens reported in this issue of Cell (Kumar et al., 2010; Tobin et al., 2010), reveal that virulent mycobacteria evade the host immune system by stimulating production of anti-inflammatory molecules and inhibiting autophagy.
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