Th17 and Regulatory T Cells in Mediating and Restraining Inflammation | Zendy

Dan R. Littman | Zendy; Alexander Y. Rudensky | Zendy

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Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

Author(s) -

Dan R. Littman,

Alexander Y. Rudensky

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.02.021

Subject(s) - biology , inflammation , microbiology and biotechnology , genetics , immunology

The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of "self" and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota.

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