Open AccessMembrane Curvature in Synaptic Vesicle Fusion and Beyond
Author(s) -
Harvey T. McMahon,
Michael M. Kozlov,
Sascha Martens
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.02.017
Subject(s) - biology , membrane curvature , vesicle fusion , vesicle , lipid bilayer fusion , synaptic vesicle , curvature , microbiology and biotechnology , biophysics , membrane , biochemistry , geometry , mathematics
Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom