Open AccessReining in H2O2 for Safe Signaling
Author(s) -
Michel B. Tolédano,
Anne-Gaëlle Planson,
A Delaunay
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.02.003
Subject(s) - biology , signal transduction , microbiology and biotechnology , computational biology , genetics
Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.
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