Immunity, Inflammation, and Cancer | Zendy

Sergei I. Grivennikov | Zendy; Florian R. Greten | Zendy; Michael Karin | Zendy

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Immunity, Inflammation, and Cancer

Author(s) -

Sergei I. Grivennikov,

Florian R. Greten,

Michael Karin

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.01.025

Subject(s) - inflammation , biology , crosstalk , immune system , immunity , immunology , cancer , metastasis , cancer research , genetics , physics , optics

Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.

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