Open AccessBlocking the Deadly Effects of the NMDA Receptor in Stroke
Author(s) -
Henry G. S. Martin,
Yu Tian Wang
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.01.014
Subject(s) - biology , nmda receptor , blocking (statistics) , stroke (engine) , neuroscience , receptor , genetics , computer science , mechanical engineering , engineering , computer network
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.
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