Open AccessDuct Tape for Broken Chromosomes
Author(s) -
Gary J. Gorbsky
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.01.005
Subject(s) - biology , mitosis , centromere , chromatin , cohesin , kinetochore , microbiology and biotechnology , polytene chromosome , neuroblast , cell division , genetics , chromosome segregation , chromosome , dna , cell , neurogenesis , gene
A cell undergoing mitosis is presented with a potentially catastrophic situation when a DNA double-strand break creates a chromosome fragment that lacks connection to a centromere. Royou et al. (2010) now reveal that this cellular crisis is averted in fruit fly neuroblasts by thin chromatin tethers that hold on to the ends of the broken chromosomes.
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