Chaperoning Histones during DNA Replication and Repair | Zendy

Monica Ransom | Zendy; Briana K. Dennehey | Zendy; Jessica K. Tyler | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chaperoning Histones during DNA Replication and Repair

Author(s) -

Monica Ransom,

Briana K. Dennehey,

Jessica K. Tyler

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.01.004

Subject(s) - chromatin , biology , histone , microbiology and biotechnology , control of chromosome duplication , histone code , dna replication , histone modifying enzymes , origin recognition complex , eukaryotic dna replication , chromatin remodeling , dna , genetics , nucleosome

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research