Chewing the Fat on Tumor Cell Metabolism | Zendy

Jessica L. Yecies | Zendy; Brendan D. Manning | Zendy

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Chewing the Fat on Tumor Cell Metabolism

Author(s) -

Jessica L. Yecies,

Brendan D. Manning

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.12.037

Subject(s) - monoacylglycerol lipase , biology , anabolism , lipid metabolism , bioenergetics , metabolism , carcinogenesis , biochemistry , lipase , glycolysis , cell growth , microbiology and biotechnology , enzyme , mitochondrion , gene , endocannabinoid system , receptor

Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.

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