Aire, Master of Many Trades | Zendy

Bruno Kyewski | Zendy; Pärt Peterson | Zendy

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Aire, Master of Many Trades

Author(s) -

Bruno Kyewski,

Pärt Peterson

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.12.036

Subject(s) - biology , autoimmune regulator , ectopic expression , repertoire , antigen , microbiology and biotechnology , central tolerance , peripheral tolerance , regulator , gene , immunology , immune tolerance , genetics , autoimmunity , immune system , physics , acoustics

In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.

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