Open AccessIntegrins and Mutant p53 on the Road to Metastasis
Author(s) -
Galina Selivanova,
Johanna Ivaska
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.12.016
Subject(s) - biology , mutant , integrin , metastasis , cancer research , computational biology , microbiology and biotechnology , genetics , gene , cancer , receptor
Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin alpha5beta1 and of epidermal growth factor receptor, promoting invasion and metastasis.
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