Open AccessItching for Insight
Author(s) -
Michael Bandell,
Ardem Patapoutian
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.12.012
Subject(s) - biology , itching , sensory system , sensation , receptor , free nerve ending , chloroquine , neuroscience , immunology , anatomy , malaria , genetics
The itch sensation results from the excitation of primary sensory nerve endings in the skin, but the underlying molecular mechanisms are not completely understood. Liu et al. (2009) now report that some members of the Mrgpr class of G protein-coupled receptors mediate the itch caused by the antimalarial drug chloroquine.
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