Open AccessFemales Battle to Suppress Their Inner Male
Author(s) -
Andrew Sinclair,
Craig A. Smith
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.11.036
Subject(s) - biology , ovary , transdifferentiation , gonad , testis determining factor , development of the gonads , embryo , microbiology and biotechnology , endocrinology , medicine , gene , genetics , stem cell , y chromosome
Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transdifferentiation of ovary into testis in adult mice, suggesting that testicular development is actively repressed throughout the life of females.
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