Open AccessX Chromosome Inactivation: When Dosage Counts
Author(s) -
Elphège P. Nora,
Édith Heard
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.11.009
Subject(s) - x inactivation , biology , x chromosome , skewed x inactivation , dosage compensation , gene , genetics , chromosome , xist , cell , microbiology and biotechnology
How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.
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