Open AccessStructure Casts Light on mtDNA Replication
Author(s) -
Maria Falkenberg,
NilsGöran Larsson
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.09.030
Subject(s) - biology , mitochondrial dna , heterotrimeric g protein , human mitochondrial genetics , mitochondrion , dna polymerase , dna replication , polymerase , genetics , microbiology and biotechnology , nuclear dna , dna , gene , signal transduction , g protein
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom