SnapShot: Pathogenesis of Parkinson's Disease | Zendy

JooHo Shin | Zendy; Valina L. Dawson | Zendy; Ted M. Dawson | Zendy

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SnapShot: Pathogenesis of Parkinson's Disease

Author(s) -

JooHo Shin,

Valina L. Dawson,

Ted M. Dawson

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.09.026

Subject(s) - biology , parkin , pathogenesis , pars compacta , substantia nigra , lrrk2 , parkinson's disease , pink1 , disease , genetics , dopaminergic , neuroscience , gene , bioinformatics , immunology , pathology , dopamine , mutation , medicine

Parkinson’s disease (PD) is the most common movement disorder characterized by death of dopaminergic neurons in the substantia nigra pars compacta. Sophisticated genetic analysis has revealed several PD-associated genes including those encoding α-synuclein, parkin, PINK1, DJ-1, LRRK2, and ATP13A2 (see table). Diverse environmental factors in conjunction with genetic risk factors lead to PD pathogenesis, although the exact mechanisms are still under investigation. This SnapShot summarizes the roles that proteins encoded by PD-associated genes play in both common and divergent mechanisms of PD pathogenesis.

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