Open AccessDNA Double-Strand Breaks Come into Focus
Author(s) -
KarlPeter Hopfner
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.09.017
Subject(s) - rad50 , biology , dna repair , dna , phosphopeptide , genetics , computational biology , microbiology and biotechnology , dna binding protein , transcription factor , phosphorylation , gene
The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.
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