PI3 Kinase Signals BCR-Dependent Mature B Cell Survival | Zendy

Lakshmi Srinivasan | Zendy; Yoshiteru Sasaki | Zendy; Dinis Pedro Calado | Zendy; Baochun Zhang | Zendy; Ji Hye Paik | Zendy; Ronald A. DePinho | Zendy; Jeffrey L. Kutok | Zendy; John F. Kearney | Zendy; Kevin L. Otipoby | Zendy; Klaus Rajewsky | Zendy

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PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

Author(s) -

Lakshmi Srinivasan,

Yoshiteru Sasaki,

Dinis Pedro Calado,

Baochun Zhang,

Ji Hye Paik,

Ronald A. DePinho,

Jeffrey L. Kutok,

John F. Kearney,

Kevin L. Otipoby,

Klaus Rajewsky

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.08.041

Subject(s) - breakpoint cluster region , biology , b cell receptor , signal transduction , transcription factor , microbiology and biotechnology , cancer research , b cell , receptor , immunology , genetics , antibody , gene

Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

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