Open AccessIroning Out a Midlife Crisis
Author(s) -
Sandra Vergara,
Dennis J. Thiele
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.06.005
Subject(s) - biology , genome instability , biogenesis , mitochondrial biogenesis , mitochondrion , genetics , cancer , instability , microbiology and biotechnology , gene , dna damage , dna , physics , mechanics
There is a strong correlation between age, genomic instability, and the development of cancer. Working in yeast, Veatch et al. (2009) now propose that defects in the biogenesis of iron-sulfur clusters arising as a consequence of mitochondrial dysfunction contribute to the increase in genomic instability as cells age.
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