THETA BURST AND STANDARD REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION FOR MAJOR DEPRESSIVE DISORDER AT A SUBURBAN TERTIARY CLINIC | Zendy

Amelia Hess | Zendy; Maria Cristina Davila | Zendy; Ananya Louviere | Zendy; Ann M. Manzardo | Zendy

Open Access

THETA BURST AND STANDARD REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION FOR MAJOR DEPRESSIVE DISORDER AT A SUBURBAN TERTIARY CLINIC

Author(s) -

Amelia Hess,

Maria Cristina Davila,

Ananya Louviere,

Ann M. Manzardo

Publication year - 2020

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2020.06.072

Subject(s) - transcranial magnetic stimulation , hamilton anxiety rating scale , rating scale , depression (economics) , beck depression inventory , hamilton rating scale for depression , anxiety , psychology , beck anxiety inventory , major depressive disorder , stimulation , deep brain stimulation , psychiatry , medicine , mood , developmental psychology , economics , macroeconomics , disease , parkinson's disease

(n1⁄414) and sham (n1⁄415) groups respectively with no severe adverse events. The trial was ended early due to superiority of the active treatment. Conclusions: SAINT, an accelerated, high-dose, rTMS protocol with fcMRIguided targeting is significantly more effective than sham treatment for TRD. Our results could guide future clinical practice towards the use of neuroscience-informed stimulation parameter choices and personalized stimulation targets. The short 5-day duration of this treatment would allow SAINT to be used in emergency settings or during acute hospitalizations to rapidly ensure the safety of suicidal depressed patients. ClinicalTrials.gov NCT03068715.

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