Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression | Zendy

Maxim Zavorotnyy | Zendy; Rebecca Zöllner | Zendy; Henning Rekate | Zendy; Patricia Dietsche | Zendy; Miriam H. A. Bopp | Zendy; Jens Sommer | Zendy; Tina Meller | Zendy; Axel Krug | Zendy; Igor Nenadić | Zendy

Open Access

Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression

Author(s) -

Maxim Zavorotnyy,

Rebecca Zöllner,

Henning Rekate,

Patricia Dietsche,

Miriam H. A. Bopp,

Jens Sommer,

Tina Meller,

Axel Krug,

Igor Nenadić

Publication year - 2020

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2020.03.015

Subject(s) - anterior cingulate cortex , transcranial magnetic stimulation , stimulation , psychology , antidepressant , neurochemical , major depressive disorder , neuroscience , creatine , dorsolateral prefrontal cortex , medicine , prefrontal cortex , neuroplasticity , hippocampus , cognition

Intermittent theta-burst stimulation (iTBS), a novel repetitive transcranial magnetic stimulation (rTMS) technique, appears to have antidepressant effects when applied over left dorsolateral prefrontal cortex (DLPFC). However, its underlying neurobiological mechanisms are unclear. Proton magnetic resonance spectroscopy ( 1 H-MRS) provides in vivo measurements of cerebral metabolites altered in major depressive disorder (MDD) like N-acetyl-aspartate (NAA) and choline-containing compounds (Cho). We used MRS to analyse effects of iTBS on the associations between the shifts in the NAA and Cho levels during therapy and MDD improvement.

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