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Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial
Author(s) -
Katharine Dunlop,
Jack Sheen,
Laura Schulze,
Peter Fettes,
Farrokh Mansouri,
Kfir Feffer,
Daniel M. Blumberger,
Zafiris J. Daskalakis,
Sidney H. Kennedy,
Peter Giacobbe,
D. Blake Woodside,
Jonathan Downar
Publication year - 2019
Publication title -
brain stimulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.685
H-Index - 81
eISSN - 1935-861X
pISSN - 1876-4754
DOI - 10.1016/j.brs.2019.10.020
Subject(s) - transcranial magnetic stimulation , randomized controlled trial , stimulation , depression (economics) , placebo , treatment resistant depression , deep transcranial magnetic stimulation , medicine , psychology , prefrontal cortex , supplementary motor area , refractory (planetary science) , anesthesia , antidepressant , physical medicine and rehabilitation , hippocampus , psychiatry , neuroscience , functional magnetic resonance imaging , cognition , macroeconomics , physics , alternative medicine , pathology , astrobiology , economics
Dorsomedial prefrontal cortex (DMPFC) repetitive transcranial magnetic stimulation (rTMS) is a novel intervention for treatment-refractory depression (TRD). To date, many open-label case series and one randomized controlled trial of modest sample size have provided preliminary evidence that DMPFC-rTMS is an effective treatment for TRD. Here, we report the results of a large, double-blinded, sham-controlled trial of DMPFC-rTMS for TRD.

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