Open AccessPerillanolides A and B, new monoterpene glycosides from the leaves of Perilla frutescens
Author(s) -
Lei Yang,
Xiaohong Liu,
Zhou San,
Hua Gao,
Guoliang Li,
Weijie Guo,
Xinyu Fang,
Wei Wang
Publication year - 2017
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2017.06.003
Subject(s) - perilla frutescens , monoterpene , chemistry , lamiaceae , luteolin , glycoside , stereochemistry , apigenin , xanthine , xanthine oxidase , botany , organic chemistry , enzyme , biochemistry , biology , flavonoid , antioxidant
Two new monoterpene glycosides, perillanolides A and B, together with a known compound reported from the genus Perilla for the first time were isolated and characterized from the leaves of Perilla frutescens (L.) Britton, Lamiaceae, a garnish and colorant for foods as well as commonly used for traditional medicine. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from nuclear magnetic resonance experiments, mass spectrometry and by comparing their physical and spectroscopic data of literature. These compounds, together with the previously isolated secondary metabolites of this species, were investigated for their inhibitory effects on xanthine oxidase in vitro. Of the compounds, luteolin showed the strongest inhibitory activity with an IC50 value of 2.18 µM. Esculetin and scutellarein moderately inhibited the enzyme, while perillanolides A and B, and 4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside exerted weak activities