Open AccessPharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases
Author(s) -
Clarice C. Veloso,
Gutemberg Soares,
Andréa C. Perez,
Vanessa Gregório Rodrigues,
Fernando César Silva
Publication year - 2017
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2017.02.006
Subject(s) - rheumatoid arthritis , compendium , traditional medicine , medicine , chemical constituents , mechanism (biology) , biology , pharmacology , chemistry , immunology , philosophy , archaeology , epistemology , chromatography , history
Uses of medicinal plants by people around the world significantly contribute and guide biologically active compounds research that can be useful in the combat against various diseases. Due to a great chemical and structural variety found in their vegetal structures it consolidates ethnopharmacology as an important science for the pharmaceutical section. Inserted in the diversity of medicinal plants, is the Maytenus genus, whose research has already revealed lots of isolated substances which are responsible for a great variety of biological activities, among which we cite analgesic and anti-inflammatory, for the treatment of inflammatory diseases such as rheumatoid arthritis, gastritis, ulcers and gastrointestinal disorders. The aim of this review article is to make a compendium of the Maytenus genus and its isolated chemical compounds, among them tingenone. The elucidation of its mechanism of action reveals promising sources for the development of new drugs specially targeted for the treatment of painful inflammatory diseases