Open AccessCytotoxic diterpenoids from the roots of Salvia lachnocalyx
Author(s) -
Hossein Hadavand Mirzaei,
Omidreza Firuzi,
Bernd Schneider,
Ian T. Baldwin
Publication year - 2017
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2017.01.009
Subject(s) - phytochemical , lamiaceae , cytotoxicity , cytotoxic t cell , stereochemistry , salvia , traditional medicine , chemistry , terpenoid , cancer cell lines , in vitro , biology , biochemistry , cancer cell , cancer , medicine , genetics
Salvia lachnocalyx Hedge, Lamiaceae, is an endemic sage which grows naturally in the Fars Province of Iran. The phytochemical analyses of the roots of S. lachnocalyx led to the isolation of five known diterpenoids: ferruginol (1), taxodione (2), sahandinone (3), 4-dehydrosalvilimbinol (4) and labda-7,14-dien-13-ol (5). Their chemical structures were elucidated using 1D (1H and 13C) and 2D (COSY, HSQC and HMBC) NMR spectroscopic data as well as EIMS. The cytotoxicity of the purified compounds was evaluated against three human cancer cell lines; MOLT-4 (acute lymphoblastic leukemia), HT-29 (colorectal adenocarcinoma) and MCF7 (breast adenocarcinoma) and all of the isolated compounds showed considerable cytotoxic activity against these cell lines. Compounds 2 and 3 (IC50 range: 0.41–3.87 μg/ml) with endocyclic α,β-unsaturated carbonyl functional group, exhibited the highest cytotoxic activities compared to the other compounds (IC50 range: 6.85–17.23 μg/ml). In conclusion, compounds 2 and 3 are presented as compounds that deserve further investigation of their biological activities