Open AccessCytotoxicity, antioxidant and antibacterial activity of four compounds produced by an endophytic fungus Epicoccum nigrum associated with Entada abyssinica
Author(s) -
Jean Paul Dzoyem,
Raduis Melong,
Armelle Tontsa Tsamo,
Timoleon Maffo,
Deccaux G. W. F. Kapche,
Bonaventure T. Ngadjui,
Lyndy Joy McGaw,
Jacobus Nicolaas Eloff
Publication year - 2017
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2016.08.011
Subject(s) - beauvericin , cytotoxicity , bacillus cereus , antibacterial activity , microbiology and biotechnology , antimicrobial , traditional medicine , antioxidant , biology , chemistry , bacteria , botany , medicine , biochemistry , fusarium , in vitro , genetics
Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 µg/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50 values ranged from 40.42 to 86.56 µg/ml, 31.87 to 86.57 µg/ml and 21.59 to 67.27 µg/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections