Open AccessCucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
Author(s) -
Sabrin R. M. Ibrahim,
Rwaida A. Al Haidari,
Gamal A. Mohamed,
Ehab S. Elkhayat,
Mohamed A. Moustafa
Publication year - 2016
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2016.03.012
Subject(s) - cucumis , phytochemical , cucurbitaceae , hela , dept , triterpenoid , chemistry , cytotoxic t cell , traditional medicine , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , botany , biology , biochemistry , cell , in vitro , medicine
Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid: cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds: α-spinasterol and D:B-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40μg/ml, respectively compared to paclitaxel (0.07 and 0.92μg/ml, respectively)