Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds | Zendy

Sabrin R. M. Ibrahim | Zendy; Rwaida A. Al Haidari | Zendy; Gamal A. Mohamed | Zendy; Ehab S. Elkhayat | Zendy; Mohamed A. Moustafa | Zendy

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Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds

Author(s) -

Sabrin R. M. Ibrahim,

Rwaida A. Al Haidari,

Gamal A. Mohamed,

Ehab S. Elkhayat,

Mohamed A. Moustafa

Publication year - 2016

Publication title -

revista brasileira de farmacognosia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 46

eISSN - 1981-528X

pISSN - 0102-695X

DOI - 10.1016/j.bjp.2016.03.012

Subject(s) - cucumis , phytochemical , cucurbitaceae , hela , dept , triterpenoid , chemistry , cytotoxic t cell , traditional medicine , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , botany , biology , biochemistry , cell , in vitro , medicine

Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid: cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds: α-spinasterol and D:B-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40μg/ml, respectively compared to paclitaxel (0.07 and 0.92μg/ml, respectively)

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