Open AccessSolanum paniculatum root extract reduces diarrhea in rats
Author(s) -
Jonh Aldson Bezerra Tenório,
Dulciana Santos do Monte,
Thelma M.G. da Silva,
Teresinha G. da Silva,
Clécio S. Ramos
Publication year - 2016
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2016.02.003
Subject(s) - loperamide , castor oil , diarrhea , feces , motility , traditional medicine , potency , biology , solanum , chemistry , food science , botany , biochemistry , medicine , microbiology and biotechnology , in vitro , genetics
olanum paniculatum L., Solanaceae, locally known as “jurubeba”, is widely used in Brazil for culinary purposes, and in folk medicine to treat of diverse disorder including gastric dysfunctions. In this study we investigated the antidiarrheal activity of S. paniculatum roots extract in rats at different concentrations (125, 250 and 500mg/kg, p.o) using different experimental models such as castor oil-induced diarrhea, enteropooling and gastrointestinal motility, determined by in vivo experimental models. The major compound of root extract was characterized as chlorogenic acid based in the IR, 1D and 2D NMR analysis. All the extract doses achieved antidiarrheal potency, as indicated by reduced weight of feces in castor oil-induced diarrhea, decreased intestinal motility and significantly inhibited castor oil-induced enteropooling compared to the vehicle group. The highest dose (500mg/kg) produced greater anti-motility effect and better reduction of enteropooling, similar to the reference drug Loperamide (5mg/kg). Extract from S. paniculatum L. roots had antidiarrheal activity, as shown by the lower weight of the feces as well as decrease in the accumulation of intestinal fluid and slower transit, justifying the traditional use of plant for diarrhea