Open AccessEvaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts
Author(s) -
Levi Pompermayer Machado,
Luciana Retz de Carvalho,
Maria Cláudia M. Young,
Elaine Monteiro Cardoso-Lopes,
Danilo da Cruz Centeno,
Leonardo Zambotti-Villela,
Pio Colepicolo,
Nair S. Yokoya
Publication year - 2015
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2015.09.003
Subject(s) - acetylcholinesterase , aché , chemistry , gas chromatography–mass spectrometry , traditional medicine , mass spectrometry , enzyme , biochemistry , chromatography , medicine
Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them