Open AccessAntimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives
Author(s) -
Marcela Carmen de Melo Burger,
Ana Paula Terezan,
Gracielle Silva de Oliveira Cunha,
João B. Fernandes,
Maria Fátima das Graças Fernandes da Silva,
Paulo Cézar Vieira,
Antônio Carlos Severo Menezes
Publication year - 2015
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2015.07.023
Subject(s) - antimicrobial , microbiology and biotechnology , micrococcus luteus , salmonella enterica , candida albicans , candida tropicalis , staphylococcus aureus , broth microdilution , biology , bacillus subtilis , minimum inhibitory concentration , chemistry , salmonella , bacteria , genetics
The antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. & Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa