Open AccessClinical safety evaluation of a tea containing Cissampelos sympodialis in healthy volunteers
Author(s) -
Liane Franco Barros Mangueira,
Luciana da Silva Nunes Ramalho,
Andressa Brito Lira,
Josué do Amaral Ramalho,
Kardilândia Mendes de Oliveira,
Aretuza Iolanda Pimentel de Almeida Torres,
Valério Marcelo Vasconcelos do Nascimento,
Caliandra Maria Bezerra Luna Lima,
Cícero Flávio Soares Aragão,
Margareth de Fátima Formiga Melo Diniz
Publication year - 2015
Publication title -
revista brasileira de farmacognosia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 46
eISSN - 1981-528X
pISSN - 0102-695X
DOI - 10.1016/j.bjp.2015.06.009
Subject(s) - medicine
Cissampelos sympodialis Eichler, Menispermaceae, is widely used by Indian tribes and folk medicine to treat various inflammatory disorders, including asthma. Clinical toxicological trials were made with the tea of C. sympodialis, a medicinal plant. The study took place at Lauro Wanderley Hospital/UFPB-PB, where seventeen healthy volunteers were chosen, among those six men and eleven women who orally ingested, during four weeks uninterruptedly, 150 ml of the tea, once a day. Before the first ingestion and after the last one, the participants were subjected to clinical and laboratorial tests for their overall conditions in order to analyze the toxicity of the plant. The results demonstrated that the volunteers neither experience clinical nor laboratorial alterations, as well as no significant adverse effects, apart from little change detected in their hematological tests. Nevertheless, none demonstrated any pathological conditions, just alterations of the normal human being physiology. Therefore, it is concluded that these data complement that obtained during pre-clinical studies and confirm a low toxicity of this plant