Open AccessRetinoic acid induces differentiation of cochlear neural progenitor cells into hair cells
Author(s) -
Minyun Chen,
Jianmin Huang
Publication year - 2021
Publication title -
brazilian journal of otorhinolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.488
H-Index - 33
eISSN - 1808-8694
pISSN - 1808-8686
DOI - 10.1016/j.bjorl.2021.01.005
Subject(s) - retinoic acid , progenitor cell , hair cell , nestin , neural stem cell , microbiology and biotechnology , cochlea , biology , progenitor , inner ear , cellular differentiation , stem cell , immunology , chemistry , cell culture , anatomy , biochemistry , genetics , gene
Inner ear progenitor cells have the potential for multi-directional differentiation. Retinoic acid is an important requirement for the development of the inner ear. Blocking the Curtyr's retinoic acid signaling pathway can significantly reduce the number of hair cells. Therefore, we believe that retinoic acid may induce the regeneration of inner ear hair cells.
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