Protective effect of creatine on amikacin-induced ototoxicity | Zendy

Emre Apaydın | Zendy; Elif Dağlı | Zendy; Sevinç Bayrak | Zendy; Ekrem Said Kankılıç | Zendy; Hasan Şahin | Zendy; Aydın Acar | Zendy

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Protective effect of creatine on amikacin-induced ototoxicity

Author(s) -

Emre Apaydın,

Elif Dağlı,

Sevinç Bayrak,

Ekrem Said Kankılıç,

Hasan Şahin,

Aydın Acar

Publication year - 2020

Publication title -

brazilian journal of otorhinolaryngology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.488

H-Index - 33

eISSN - 1808-8694

pISSN - 1808-8686

DOI - 10.1016/j.bjorl.2020.09.002

Subject(s) - amikacin , ototoxicity , auditory brainstem response , creatine monohydrate , medicine , creatine , anesthesia , intramuscular injection , pharmacology , hearing loss , antibiotics , chemistry , audiology , chemotherapy , biochemistry , pathology , alternative medicine , cisplatin , placebo

Aminoglycosides are widely known for their ototoxic side effects. Nevertheless, they are potent antibiotics used in the treatment of life-threatening conditions because of the current concern for antibiotic resistance. We hypothesized that creatine supplements which are believed to improve mitochondrial antioxidant defense system and maintain optimal energy homeostasis may improve the ototoxic side effects.

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