The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese | Zendy

Qian Wang | Zendy; Sichao Sun | Zendy; Qinggao Song | Zendy; Huan Hu | Zendy; Jiaxing An | Zendy; Jianguo Liu | Zendy

Open Access

The risk of nonsyndromic cleft lip with or without cleft palate and Vax1 rs7078160 polymorphisms in southern Han Chinese

Author(s) -

Qian Wang,

Sichao Sun,

Qinggao Song,

Huan Hu,

Jiaxing An,

Jianguo Liu

Publication year - 2020

Publication title -

brazilian journal of otorhinolaryngology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.488

H-Index - 33

eISSN - 1808-8694

pISSN - 1808-8686

DOI - 10.1016/j.bjorl.2020.08.007

Subject(s) - medicine , genotype , sanger sequencing , chinese population , genetics , dentistry , pediatrics , gene , biology , dna sequencing

Non-syndromic cleft lip with or without cleft palate is a common worldwide birth defect due to a combination of environmental and genetic factors. Genome-wide association studies reported the rs7078160 of Vax1 is closely related to non-syndromic cleft lip with or without cleft palate in European populations. The following studies showed the same results in Mongolian, Japanese, Filipino, Vietnamese populations etc. However, conflicting research had been reported in Chinese population, OBJECTIVE: The aim of this study was to investigate the association between the rs7078160 polymorphism and non-syndromic cleft lip with or without cleft palate in Southern Chinese patients.

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