The role of CSE1L expression in cervical lymph node metastasis of larynx tumors | Zendy

Tuncay Tunçcan | Zendy; Sertaç Düzer | Zendy; Gülay Dilek | Zendy; Ulvi M. Yuksel | Zendy; Hasan Çetiner | Zendy; Caner Kılıç | Zendy; Ayça Ant | Zendy; Arzu Betul Duran | Zendy

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The role of CSE1L expression in cervical lymph node metastasis of larynx tumors

Author(s) -

Tuncay Tunçcan,

Sertaç Düzer,

Gülay Dilek,

Ulvi M. Yuksel,

Hasan Çetiner,

Caner Kılıç,

Ayça Ant,

Arzu Betul Duran

Publication year - 2019

Publication title -

brazilian journal of otorhinolaryngology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.488

H-Index - 33

eISSN - 1808-8694

pISSN - 1808-8686

DOI - 10.1016/j.bjorl.2019.06.010

Subject(s) - larynx , metastasis , medicine , lymph node , immunohistochemistry , pathology , cervical lymph nodes , cancer , chromosome , lymph node metastasis , oncology , cancer research , biology , gene , anatomy , genetics

According to international reports, 30-40% of all head and neck cancers are larynx cancers, comprising 1-2.5% of all cancer types. Cervical nodal involvement has been reported to be 40% and 65% in T3 and T4 cases, respectively. Five-year survival in patients with cervical lymph node metastasis has been demonstrated to be 50% lower compared to patients with no metastasis. Chromosome segregation like 1 protein; is a DNA fragment isolated by Brinkmann et al. in 1995 that corresponds to yeast chromosome segregation protein. Studies on the effect of chromosome segregation like 1 protein expression in head and neck tumors are rare and it has been shown that nuclear chromosome segregation like 1 protein is over-expressed in these studies where gastrointestinal and breast tumors over-expressed cytoplasmic chromosome segregation like 1 protein.

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